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Chemical Structure : Gambogic amide
Catalog No.: PC-70266Not For Human Use, Lab Use Only.
A potent, selective high affinity TrkA receptor agonist with Kd of 75 nM.
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A potent, selective high affinity TrkA receptor agonist with Kd of 75 nM; selectively binds to TrkA, but not TrkB or TrkC, and robustly induces its tyrosine phosphorylation and downstream signaling activation, including Akt and MAPKs; potently represses cyclin A1 expression and blocks K562 cell proliferation; diminishes kainic acid-triggered neuronal cell death and decreases infarct volume in the transient middle cerebral artery occlusion model of stroke in mice.
| M.Wt | 627.778 | |
| Formula | C38H45NO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jang SW, et al. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16329-34.
2. Chan CB, et al. Oncogene. 2009 Oct 29;28(43):3825-36.
3. Obianyo O, et al. Biochim Biophys Acta. 2013 Oct;1834(10):2213-8.
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