Gambogic amide | TrkA agonist | Probechem Biochemicals

Chemical Structure : Gambogic amide

Gambogic amide (TrkA agonist)

Catalog No.: PC-70266Not For Human Use, Lab Use Only.

Gambogic amide is a potent, selective high affinity TrkA receptor agonist with Kd of 75 nM.

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Biological Activity

Gambogic amide is a potent, selective high affinity TrkA receptor agonist with Kd of 75 nM.
Gambogic amide selectively binds to TrkA, but not TrkB or TrkC, and robustly induces its tyrosine phosphorylation and downstream signaling activation, including Akt and MAPKs.
Gambogic amide potently represses cyclin A1 expression and blocks K562 cell proliferation.
Gambogic amide diminishes kainic acid-triggered neuronal cell death and decreases infarct volume in the transient middle cerebral artery occlusion model of stroke in mice.

Physicochemical Properties

M.Wt	627.778
Formula	C38H45NO7
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-4-((1S,3aR,5S,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-1,2,5,7-tetrahydro-11H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a(4H)-yl)-2-methylbut-2-enamide

References

1. Jang SW, et al. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16329-34.

2. Chan CB, et al. Oncogene. 2009 Oct 29;28(43):3825-36.

3. Obianyo O, et al. Biochim Biophys Acta. 2013 Oct;1834(10):2213-8.