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Chemical Structure : Gambogic amide
Catalog No.: PC-70266Not For Human Use, Lab Use Only.
Gambogic amide is a potent, selective high affinity TrkA receptor agonist with Kd of 75 nM.
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Gambogic amide is a potent, selective high affinity TrkA receptor agonist with Kd of 75 nM.
Gambogic amide selectively binds to TrkA, but not TrkB or TrkC, and robustly induces its tyrosine phosphorylation and downstream signaling activation, including Akt and MAPKs.
Gambogic amide potently represses cyclin A1 expression and blocks K562 cell proliferation.
Gambogic amide diminishes kainic acid-triggered neuronal cell death and decreases infarct volume in the transient middle cerebral artery occlusion model of stroke in mice.
| M.Wt | 627.778 | |
| Formula | C38H45NO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jang SW, et al. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16329-34.
2. Chan CB, et al. Oncogene. 2009 Oct 29;28(43):3825-36.
3. Obianyo O, et al. Biochim Biophys Acta. 2013 Oct;1834(10):2213-8.
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