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Chemical Structure : Garcinol
CAS No.: 78824-30-3
Catalog No.: PC-62558Not For Human Use, Lab Use Only.
Garcinol (Camboginol) is a potent, natural inhibitor of histone acetyltransferases (HATs) p300 (IC50=7 uM) and PCAF (IC50=5 uM) both in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Garcinol (Camboginol) is a potent, natural inhibitor of histone acetyltransferases (HATs) p300 (IC50=7 uM) and PCAF (IC50=5 uM) both in vitro and in vivo.
Garcinol (Camboginol) downregulates various cell survival proteins including survivin, bcl-2, XIAP, and cFLIP, and induces bid cleavage, bax, and cytochrome c release.
Garcinol (Camboginol) potentiates TRAIL-induced apoptosis through upregulation of death receptors and downregulation of antiapoptotic proteins.
Garcinol (Camboginol) also siimulates neurogenesis and ex vivo expansion of human hematopoietic stem cells.
| M.Wt | 602.812 | |
| Formula | C38H50O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-bicyclo[3.3.1]non-3-ene-2,9-dione |
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1. Balasubramanyam K, et al. J Biol Chem. 2004 Aug 6;279(32):33716-26.
2. Prasad S, et al. Mol Cancer Ther. 2010 Apr;9(4):856-68.
3. Nishino T, et al. PLoS One. 2011;6(9):e24298.
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