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Chemical Structure : Gatorbulin-1
Catalog No.: PC-23470Not For Human Use, Lab Use Only.
Gatorbulin-1 (GB1) is a microtubule-destabilizing cyclodepsipeptide, directly inhibits tubulin polymerization in vitro in an iron-independent manner.
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Gatorbulin-1 (GB1) is a microtubule-destabilizing cyclodepsipeptide, directly inhibits tubulin polymerization in vitro in an iron-independent manner.
Gatorbulin-1 inhibits response by 50% (IC50) of 0.80 µM in a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay against HCT116 colorectal cancer cells.
Gatorbulin-1 competes a fluorescent probe of the colchicine site with binding affinity of 1.01 uM.
Gatorbulin-1 promotes microtubule depolymerization in A-10 (rat smooth muscle) interphase cells.
| M.Wt | 483.48 | |
| Formula | C20H29N5O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Susan Matthew, et al. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2021847118.
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