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Gatorbulin-1

Chemical Structure : Gatorbulin-1

CAS No.: 2756436-12-9

Gatorbulin-1 (GB1)

Catalog No.: PC-23470Not For Human Use, Lab Use Only.

Gatorbulin-1 (GB1) is a microtubule-destabilizing cyclodepsipeptide, directly inhibits tubulin polymerization in vitro in an iron-independent manner.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Gatorbulin-1 (GB1) is a microtubule-destabilizing cyclodepsipeptide, directly inhibits tubulin polymerization in vitro in an iron-independent manner.
Gatorbulin-1 inhibits response by 50% (IC50) of 0.80 µM in a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay against HCT116 colorectal cancer cells.
Gatorbulin-1 competes a fluorescent probe of the colchicine site with binding affinity of 1.01 uM.
Gatorbulin-1 promotes microtubule depolymerization in A-10 (rat smooth muscle) interphase cells.

Physicochemical Properties

M.Wt 483.48
Formula C20H29N5O9
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-hydroxy-2-((3S,6S,9S,16S,17aS)-8-hydroxy-3,5,9,16-tetramethyl-12-methylene-1,4,7,10,13-pentaoxotetradecahydro-1H,3H-pyrrolo[2,1-c][1]oxa[4,7,10,13]tetraazacyclopentadecin-6-yl)acetamide

References

1. Susan Matthew, et al. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2021847118.

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