Gboxin | OXPHOS inhibitor | Probechem Biochemicals

Chemical Structure : Gboxin

CAS No.: 2101315-36-8

Gboxin (Oxidative phosphorylation inhibitor)

Catalog No.: PC-36144Not For Human Use, Lab Use Only.

Gboxin is a small molecule oxidative phosphorylation inhibitor that specifically inhibits the growth of primary mouse and human glioblastoma cells, but not cycling primary MEFs or astrocytes.

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10 mg	$198	In stock
25 mg	$298	In stock
100 mg	$588	In stock
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Biological Activity

Gboxin is a small molecule oxidative phosphorylation inhibitor that specifically inhibits the growth of primary mouse and human glioblastoma cells, but not cycling primary MEFs or astrocytes.

Gboxin inhibits cellular oxygen consumption and interacts with GBM OxPhos proteins, mirrors oligomycin activity and resistance requires functional mPTP.

Gboxin specifically inhibits the growth of primary mouse and human glioblastoma cells (primary GBM IC50=150 nM) but not that of mouse embryonic fibroblasts or neonatal astrocytes.

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma, inhibits the activity of F0F1 ATP synthase, mirrors oligomycin activity and resistance requires functional mPTP.

Gboxin targets unique features of mitochondrial pH in GBM and other cancer cells, independent of their genetic composition, and exerts its tumor cell specific toxicity in primary culture and in vivo.

Physicochemical Properties

M.Wt	392.968
Formula	C22H33ClN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-ethyl-1-(2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-3-methyl-1H-benzo[d]imidazol-3-ium chloride

References

1. Shi Y, et al. Nature. 2019 Mar;567(7748):341-346.

Gboxin (Oxidative phosphorylation inhibitor)

Biological Activity

Physicochemical Properties

References

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