Gemcabene (PD-72953, PD72953) calcium is a first-in-class lipid-lowering agent and activator of PARP.
Gemcabene down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism, inhibits IL-6 plus IL-1β-induced CRP production in a concentration-dependent manner in human hepatoma cells, reaching 70% inhibition at 2 mM.
Gemcabene lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), attenuates osteoarthritis and pain in animal models of arthritis and Pain.
Physicochemical Properties
M.Wt
340.473
Formula
C16H28CaO5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid calcium salt
References
1. Bisgaier CL, et al. J Lipid Res. 1998 Jan;39(1):17-30.
2. Bays HE, et al. Am J Cardiol. 2003 Sep 1;92(5):538-43.
