Gemnelatinib (GST-HG161)

Chemical Structure : Gemnelatinib

Catalog No.: PC-38395Not For Human Use, Lab Use Only.

Gemnelatinib (GST-HG161) is a potent and highly selective, orally bioavailable c-Met inhibitor, displays significant antitumor activity in preclinical models, has the potential to be effective in HCC with active c-Met signaling.

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Biological Activity

Gemnelatinib (GST-HG161) is a potent and highly selective, orally bioavailable c-Met (HFGR) inhibitor, displays significant antitumor activity in preclinical models, has the potential to be effective in HCC with active c-Met signaling.

Physicochemical Properties

M.Wt	524.600
Formula	C30H29FN6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5'-fluoro-1'-(1-(3-(5-((1-methylpiperidin-4-yl)methoxy)pyrimidin-2-yl)phenyl)ethyl)-6'-oxo-1',6'-dihydro-[2,3'-bipyridine]-4-carbonitrile

References

1. Jin Li, et al. 2020 ASCO Annual Meeting I.

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