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Gemopatrilat

Chemical Structure : Gemopatrilat

CAS No.: 160135-92-2

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Gemopatrilat (BMS-189921, BMS189921)

Catalog No.: PC-60710Not For Human Use, Lab Use Only.

Gemopatrilat (BMS-189921, BMS189921) potent, orally available, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 12 and 63 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Gemopatrilat (BMS-189921, BMS189921) potent, orally available, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 12 and 63 nM, respectively.
    Gemopatrilat causes prolonged inhibition of circulating and renal ACE and renal NEP after a single oral dose in atherogenic diet rabbits.

    Physicochemical Properties

    M.Wt 378.49
    Formula C19H26N2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-[(6S)-2,2-dimethyl-7-oxo-6-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]azepan-1-yl]acetic acid

    References

    1. Hubner RA, et al. J Hypertens. 2001 May;19(5):941-6.

    2. Singh J, et al. Org Lett. 2003 Aug 21;5(17):3155-8.

    3. Robl JA, et al. J Med Chem. 1999 Jan 28;42(2):305-11.

    4. Laverman GD, et al. Kidney Int. 2003 Jan;63(1):64-71.

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