Catalog No.: PC-43033Not For Human Use, Lab Use Only.
Gilteritinib (ASP2215) is a potent FLT3/AXL inhibitor with IC50 of 0.73 nM/0.29 nM respectively; also inhibits LTK and ALK (IC50=0.35 nM and 1.2 nM respectively).
Gilteritinib (ASP2215) is a potent FLT3/AXL inhibitor with IC50 of 0.73 nM/0.29 nM respectively; also inhibits LTK and ALK (IC50=0.35 nM and 1.2 nM respectively).
Gilteritinib (ASP2215) shows >800-fold selectivity over c-Kit.
Gilteritinib (ASP2215) inhibits the growth of Ba/F3 cells expressing either FLT3-ITD, FLT3-D835Y, FLT3-ITD-D835Y, FLT3-ITD-F691 L, and FLT3-ITD-F691I, with IC50 of 1.8 nM, 1.6 nM, 2.1 nM, 22 nM, and 49 nM, respectively.
Gilteritinib (ASP2215) is orally bioactive.
