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Chemical Structure : Giripladib
CAS No.: 865200-20-0
Catalog No.: PC-22786Not For Human Use, Lab Use Only.
Giripladib (PLA-695) is a potent, specific cytoplasmic phospholipase A2 (cPLA2).
PLA-695 inhibits radiation induced phosphorylation of ERK and Akt in cultured endothelial cells.
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|---|---|---|---|
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
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| 100 mg | Get quote |
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Giripladib (PLA-695) is a potent, specific cytoplasmic phospholipase A2 (cPLA2).
PLA-695 inhibits radiation induced phosphorylation of ERK and Akt in cultured endothelial cells.
PLA-695 in combination with irradiation prevented endothelial cell migration.
PLA-695 enhanced radiation induced cell death and attenuated invasion of lung cancer cells.
PLA-695 inhibited the formation of new blood vessels and angiogenesis.
| M.Wt | 745.25 | |
| Formula | C41H36ClF3N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(3-(1-benzhydryl-5-chloro-2-(2-(((2-(trifluoromethyl)phenyl)methyl)sulfonamido)ethyl)-1H-indol-3-yl)propyl)benzoic acid |
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1. Thotala D, et al. PLoS One. 2013 Jul 19;8(7):e69688.
2. Duvernay MT, et al. Biochemistry. 2015 Sep 15;54(36):5578-88.
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