Glecaprevir | HCV NS3/4A inhibitor | Probechem Biochemicals

Chemical Structure : Glecaprevir

CAS No.: 1365970-03-1

Glecaprevir (ABT-493, A1282576)

Catalog No.: PC-61941Not For Human Use, Lab Use Only.

Glecaprevir (ABT-493, A1282576) is a potent HCV NS3/4A protease inhibitor with pan-genotypic activity, inhibits NS3/4A proteases from HCV genotypes 1-6 in vitro with IC50 of 3.5-11.3 nM.

Packing	Price	Stock
10 mg	$78	In stock
25 mg	$128	In stock
50 mg	$218	In stock
100 mg	$358	In stock
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Biological Activity

Glecaprevir (ABT-493, A1282576) is a potent HCV NS3/4A protease inhibitor with pan-genotypic activity, inhibits NS3/4A proteases from HCV genotypes 1-6 in vitro with IC50 of 3.5-11.3 nM.
Glecaprevir inhibits the replication of stable HCV subgenomic replicons genotypes 1-6 with EC50 of 0.21-4.6 nM, has a median EC50 of 0.30 nM (0.05 - 3.8 nM) for HCV replicons containing proteases from 40 HCV genotype 1-5 samples.
The combination of ABT-493 and ABT-530 demonstrates potent antiviral activity and acceptable safety in clinical trails with HCV genotype 1 infection.

Physicochemical Properties

M.Wt	838.87
Formula	C38H46F4N6O9S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(33R,35S,91R,92R,5S,E)-5-(tert-butyl)-N-((1R,2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl)sulfonyl)carbamoyl)cyclopropyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35

References

1. Lawitz EJ, et al. Antimicrob Agents Chemother. 2015 Dec 28;60(3):1546-55.

2. Gane E, et al. Gastroenterology. 2016 Oct;151(4):651-659.e1.

3. Poordad F, et al. Hepatology. 2017 Aug;66(2):389-397.

Glecaprevir (ABT-493, A1282576)

Biological Activity

Physicochemical Properties

References

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