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Glimepiride

Chemical Structure : Glimepiride

CAS No.: 93479-97-1

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Glimepiride (HOE-490, HOE490)

Catalog No.: PC-28334Not For Human Use, Lab Use Only.

Glimepiride (HOE-490) is a sulfonylurea anti-diabetic compound that blocks the ATP-sensitive potassium channel, binds to inhibits to the sulfonylurea receptor 1 (SUR1/Kir6.2) component of ATP sensitive potassium (K ATP) channels located on pancreatic beta cells, shows binding IC50 of 3.0 nM for SUR1, 5.4 nM for SUR2A and 7.3 nM for SUR2B.

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500 mg $38 In stock
1 g $58 In stock
5 g $128 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Glimepiride (HOE-490) is a sulfonylurea anti-diabetic compound that blocks the ATP-sensitive potassium channel, binds to inhibits to the sulfonylurea receptor 1 (SUR1/Kir6.2) component of ATP sensitive potassium (K ATP) channels located on pancreatic beta cells, shows binding IC50 of 3.0 nM for SUR1, 5.4 nM for SUR2A and 7.3 nM for SUR2B.

Physicochemical Properties

M.Wt 490.62
Formula C24H34N4O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Ethyl-4-methyl-N-(4-(N-((rel-(1r,4r)-4-methylcyclohexyl)carbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

References

1. Hu S, et al. J Pharmacol Exp Ther. 2000 May;293(2):444-52.

2. Gribble FM, et al. Metabolism. 2000 Oct;49(10 Suppl 2):3-6.

3. Song DK, et al. Br J Pharmacol. 2001 May;133(1):193-9.

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