Gliocidin | IMPDH inhibitor, Influenza inhibitor

Chemical Structure : Gliocidin

CAS No.: 62289-81-0

Gliocidin (SW106065)

Catalog No.: PC-61648Not For Human Use, Lab Use Only.

Gliocidin (SW106065) is a broad influenza virus inhibitor acting via IMP dehydrogenase (IMPDH), also is an apoptosis inducer in MPNST (malignant peripheral nerve sheath tumors) with EC50 of 1 uM.

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10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

Gliocidin (SW106065) is a broad influenza virus inhibitor acting via IMP dehydrogenase (IMPDH), also is an apoptosis inducer in MPNST (malignant peripheral nerve sheath tumors) with EC50 of 1 uM.
Gliocidin (SW106065) is a prodrug that is anabolized into its tumoricidal metabolite, gliocidin–adenine dinucleotide (GAD) by NMNAT1 enzyme, targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2 (IMPDH2), induces cell death in GBM cells with IC50 of 200 nM.

SW106065 inhibits ATP consumption of sMPNST and other models of MPNST with EC50 of 1 uM, shows no toxicity to normally dividing Schwann cells or mouse embryonic fibroblasts; reduces MPNST burden in a mouse allograft model.CPD A inhibits RNA synthesis of IAV and IBV with EC50 values of 2.3 μM and 2.6 μM, respectively.

SW106065 also displays robust in vitro activity against a broad panel of IAV (H1N1 and H3N2) and IBV strains with median EC50 of 0.2 uM, with no significant cytotoxic effect.

SW106065 inhibits IMP dehydrogenase (IMPDH) and causes strong depletion of the cellular GTP pool.

SW106065 exhibits strongly synergistic effect when combined with another IMPDH inhibitor ribavirin.

Physicochemical Properties

M.Wt	204.247
Formula	C10H8N2OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(pyridin-3-yl)thiophene-2-carboxamide

References

1. Chau V, et al. Cancer Res. 2014 Jan 15;74(2):586-97.

Gliocidin (SW106065)

Biological Activity

Physicochemical Properties

References

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