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Chemical Structure : GluN2A PAM (R)-9
Catalog No.: PC-20368Not For Human Use, Lab Use Only.
GluN2A PAM (R)-9 is a potent, brain penetrant, GluN2A-selective positive allosteric modulator with EC50 of 0.51 uM, Emax 350%.
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GluN2A PAM (R)-9 is a potent, brain penetrant, GluN2A-selective positive allosteric modulator with EC50 of 0.51 uM, Emax 350%.
GluN2A PAM (R)-9 shows good NMDA-subtype selectivity, with>59-fold selectivity for GluN2B and 2C and 19-fold selectivity for GluN2D in the Ca2+ influx assay using CHO cells.
GluN2A PAM (R)-9 (10 mg/kg) significantly enhances long-term potentiation in the rat hippocampus 24 h after oral administration.
| M.Wt | 380.78 | |
| Formula | C16H15ClF2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sakurai F, et al. Bioorg Med Chem. 2022 Feb 15;56:116576.
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