Chemical Structure : GluN2A PAM Y36
CAS No.:
GluN2A PAM Y36
Catalog No.: PC-25186Not For Human Use, Lab Use Only.
GluN2A PAM Y36 is a potent, GluN2A-selective N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 24.97 uM, Emax=397.7%.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GluN2A PAM Y36 is a potent, GluN2A-selective N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 24.97 uM, Emax=397.7%.
Y36 showed higher efficacy (Emax = 397.7%) than GNE-3419 (Emax = 196.4%), reducing the EC50 values and increasing the Emax values for glutamate/glycine at GluN2A receptor.
Y36 significantly alleviated depression-related behaviors in multiple behavioral assessments in chronic restraint stress (CRS) mice.
Y36 has favorable pharmacokinetic (PK) profiles and blood-brain barrier (BBB) penetration, with no signs of addiction, weight gain, or organ and tissue damage in mice.
Physicochemical Properties
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M.Wt
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373.45
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Formula
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C19H20FN3O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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7-((4-(4-Fluorophenyl)-4-hydroxypiperidin-1-yl)methyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
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References
1. Tingting Yang, et al. J Med Chem. 2025 Jul 31. doi: 10.1021/acs.jmedchem.5c01173.
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