GluN2B NAM 12 | GluN2B NAM | Probechem Biochemicals

Chemical Structure : GluN2B NAM 12

GluN2B NAM 12 (GluN2B negative allosteric modulator 12)

Catalog No.: PC-21036Not For Human Use, Lab Use Only.

GluN2B NAM 12 (GluN2B negative allosteric modulator 12) is a selective negative allosteric modulator of GluN2B NMDAR with IC50 of 31 nM and Ki of 15 nM (hGluN2B).

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Biological Activity

GluN2B NAM 12 (GluN2B negative allosteric modulator 12) is a selective negative allosteric modulator of GluN2B NMDAR with IC50 of 31 nM and Ki of 15 nM (hGluN2B).
GluN2B NAM 12 also show high potency against GluN2B rat with Ki of 16 nM.
GluN2B NAM 12 displays no significant activity against GluN2- A/C/D (IC50 >10 uM).
GluN2B NAM 12 shows robust target engagement in rat with an ED70 of 1.4 mg/kg.

Physicochemical Properties

M.Wt	396.39
Formula	C17H15F3N4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1N(C)C2=NC=C(C3=CC=C(C(F)(F)F)S3)C=C2N1CC(N4CCC4)=O

References

1. Christa C Chrovian, et al. J Med Chem. 2020 Sep 10;63(17):9181-9196.

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GluN2B NAM 12 (GluN2B negative allosteric modulator 12)

Biological Activity

Physicochemical Properties

References

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