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Glutipyran

Chemical Structure : Glutipyran

CAS No.: 350993-69-0

Glutipyran

Catalog No.: PC-47016Not For Human Use, Lab Use Only.

Glutipyran is a small-molecule glucose transporter inhibitor, inhibits glycolytic activity and cell growth in human pancreatic cancer cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Glutipyran is a small-molecule glucose transporter inhibitor, inhibits glycolytic activity and cell growth in human pancreatic cancer cells.
Glutipyran inhibited glucose uptake and suppressed the growth of various cancer cells, including A431 cells that express glucose transporter class I (GLUT1) and DLD-1 GLUT1 knockout cells.
Glutipyran exhibited a synergistic antiproliferative effect, when combined with the mitochondrial respiration inhibitor metformin.
Glutipyran markedly decreased most metabolites of the glycolytic pathway and the pentose phosphate pathway.
Glutipyran significantly suppressed tumor growth in a xenograft mouse model of pancreatic cancer.

Physicochemical Properties

M.Wt 491.628
Formula C30H37NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Makoto Kawatani, et al. ACS Chem Biol. 2021 Aug 20;16(8):1576-1586.

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