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Glutor

Chemical Structure : Glutor

CAS No.: 2561471-22-3

Glutor (Glucose uptake inhibitor Glutor)

Catalog No.: PC-73034Not For Human Use, Lab Use Only.

Glutor (Glucose uptake inhibitor Glutor) is a novel highly potent glucose uptake inhibitor (IC50=10.8 nM) that selectively targets glucose transporters GLUT-1, -2, and -3.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Glutor (Glucose uptake inhibitor Glutor) is a novel highly potent glucose uptake inhibitor (IC50=10.8 nM) that selectively targets glucose transporters GLUT-1, -2, and -3.
Glutor reduced the uptake of 2-DG with similar potency in different cancer cell lines such as HCT116 (IC50 =10.8 nM), UM-UC-3 (IC50=8.3 nM), UO31 (IC50=3.6 nM), and MIA PaCa-2 (IC50=1.1 nM).
Glutor did not interfere with cellular hexokinase activity and potently reduced glycolytic flux in HCT116 cells.
Glutor induced upregulation of GLUT-1 and -3 in cancer cells, inhibited glycolysis and efficiently suppresseed the growth of various cancer cell lines.
Glutor potently and synergistically inhibited colon cancer cell growth combined with glutaminase inhibitor CB-839.

Physicochemical Properties

M.Wt 536.636
Formula C31H32N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-6-methyl-5-(4-morpholinobenzyl)-4-oxo-2-phenyl-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-6-carboxamide

References

1. Reckzeh ES, et al. Cell Chem Biol. 2019 Sep 19;26(9):1214-1228.e25.

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