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Chemical Structure : GlyT1 inhibitor 46
Catalog No.: PC-35393Not For Human Use, Lab Use Only.
GlyT1 inhibitor 46 is a novel potent, selective, orally available inhibitor of glycine transporter-1 (GlyT1) with IC50 of 38 and 21 nM for rat and human GlyT1, respectively.
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GlyT1 inhibitor 46 is a novel potent, selective, orally available inhibitor of glycine transporter-1 (GlyT1) with IC50 of 38 and 21 nM for rat and human GlyT1, respectively.
GlyT1 inhibitor 46 demonstrates in vivo efficacy in a rat novel object recognition (NOR) assay after oral dosing at 0.1, 1, and 3 mg/kg.
| M.Wt | 387.443 | |
| Formula | C22H21N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Santora VJ, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.8b00372.
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