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GlyT1 inhibitor 46

Chemical Structure : GlyT1 inhibitor 46

CAS No.: 1820934-93-7

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GlyT1 inhibitor 46

Catalog No.: PC-35393Not For Human Use, Lab Use Only.

GlyT1 inhibitor 46 is a novel potent, selective, orally available inhibitor of glycine transporter-1 (GlyT1) with IC50 of 38 and 21 nM for rat and human GlyT1, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GlyT1 inhibitor 46 is a novel potent, selective, orally available inhibitor of glycine transporter-1 (GlyT1) with IC50 of 38 and 21 nM for rat and human GlyT1, respectively.
    GlyT1 inhibitor 46 demonstrates in vivo efficacy in a rat novel object recognition (NOR) assay after oral dosing at 0.1, 1, and 3 mg/kg.

    Physicochemical Properties

    M.Wt 387.443
    Formula C22H21N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-[2-(2-Methylpyridin-4-yl)-2H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile

    References

    1. Santora VJ, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.8b00372.

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