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Chemical Structure : Goflikicept
CAS No.:
Catalog No.: PC-38883Not For Human Use, Lab Use Only.
Goflikicept (RPH-104) is a heterodimeric fusion protein containing IL-1R1 and IL-1RAcP linked to immunoglobulin heavy chains and is highly selectively binds IL-1B, affecting IL-1B signalling pathways, inhibits widespread inflammation.
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Goflikicept (RPH-104) is a heterodimeric fusion protein containing IL-1R1 and IL-1RAcP linked to immunoglobulin heavy chains and is highly selectively binds IL-1B, affecting IL-1B signalling pathways, inhibits widespread inflammation.
Human interleukin-1 receptor accessory protein fragment (21-358, 1-338 in the current sequence) fused via peptidyl linker 339GSGGG343 to a human immunoglobulin G1 Fc fragment (344-570, C-terminal Lys clipped) variant (S>C477, T>W489, K>A532), covalent dimer with human interleukin-1 receptor type 1 fragment (21-333, 1-313 in the current sequence) fused via peptidyl linker 314GSGG318 to a human immunoglobulin G1 Fc fragment (319-545, C-terminal Lys clipped) variant (Y>C447, T>S464, L>A466, F>K503, Y>V505), glycosylated, produced in Chinese hamster ovary (CHO) cells.
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