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GpTx-1

Chemical Structure : GpTx-1

CAS No.: 1661050-12-9

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GpTx-1 (GpTx1)

Catalog No.: PC-63263Not For Human Use, Lab Use Only.

GpTx-1 is a potent, selective, 34-residue peptide antagonist of Nav1.7 sodium channel with IC50 of 10 nM, displays 20- and 1000- fold selectivity over NaV1.4 and NaV1.5..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GpTx-1 is a potent, selective, 34-residue peptide antagonist of Nav1.7 sodium channel with IC50 of 10 nM, displays 20- and 1000- fold selectivity over NaV1.4 and NaV1.5.

    Physicochemical Properties

    M.Wt
    Formula C176H271N53O45S7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    H-Asp-Cys-Leu-Gly-Phe-Met-Arg-Lys-Cys-Ile-Pro-Asp-Asn-Asp-Lys-Cys-Cys-Arg-Pro-Asn-Leu-Val-Cys-Ser-Arg-Thr-His-Lys-Trp-Cys-Lys-Tyr-Val-Phe-NH2

    References

    1. Murray JK, et al. J Med Chem. 2015 Mar 12;58(5):2299-314.

    2. Deuis JR, et al. Toxins (Basel). 2016 Mar 17;8(3). pii: E78.

    3. Biswas K, et al. ACS Chem Biol. 2017 Sep 15;12(9):2427-2435.

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