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Guggulsterone

Chemical Structure : Guggulsterone

CAS No.: 95975-55-6

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Guggulsterone (Z/E-Guggulsterone)

Catalog No.: PC-27267Not For Human Use, Lab Use Only.

Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii, inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), inhibits the proliferation of HL60 and U937 cells with IC50 of 3.6-10.9 uM, also is a farnesoid X receptor (FXR) antagonist.

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10 mg $78 In stock
25 mg $128 In stock
50 mg $198 In stock
100 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii, inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), inhibits the proliferation of HL60 and U937 cells with IC50 of 3.6-10.9 uM, also is a farnesoid X receptor (FXR) antagonist.

Physicochemical Properties

M.Wt 312.45
Formula C21H28O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(8R,9S,10R,13S,14S)-17-Ethylidene-10,13-dimethyl-7,8,9,10,11,12,13,14,15,17-decahydro-1H-cyclopenta[a]phenanthrene-3,16(2H,6H)-dione

References

1. Tripathi YB, et al. Planta Med. 1984 Feb;50(1):78-80.

2. Mester L, et al. Planta Med. 1979 Dec;37(4):367-9.

3. Samudio I, et al. Mol Cancer Ther. 2005 Dec;4(12):1982-92.

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