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H-PGDS inhibitor 1y

Chemical Structure : H-PGDS inhibitor 1y

CAS No.: 2255311-93-2

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H-PGDS inhibitor 1y

Catalog No.: PC-49637Not For Human Use, Lab Use Only.

H-PGDS inhibitor 1y is a potent peripherally restricted hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 of 9.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    H-PGDS inhibitor 1y is a potent peripherally restricted hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 of 9.4 nM.
    compound 1y is efficacious in four in vivo inflammatory models and exhibits no CNS toxicity.

    Physicochemical Properties

    M.Wt 353.47
    Formula C21H27N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-cyclopropyl-N-((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-1,8-naphthyridine-3-carboxamide

    References

    1. Rodolfo Cadilla, et al. Bioorg Med Chem. 2020 Dec 1;28(23):115791.

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