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Chemical Structure : HA14-1
CAS No.: 65673-63-4
Catalog No.: PC-42826Not For Human Use, Lab Use Only.
HA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM, induces apoptosis of tumor cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $38 | In stock | |
| 25 mg | $58 | In stock | |
| 100 mg | $98 | In stock | |
| 250 mg | Get quote | ||
| 250 mg | Get quote |
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HA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM, induces apoptosis of tumor cells.
HA14-1 effectively induces apoptosis of HL-60 cells overexpressing Bcl-2 protein associated with the decrease in mitochondrial membrane potential and activation of caspase-9 followed by caspase-3.
HA14-1 strongly induces the death of NIH 3T3 (Apaf-1(+/+)) cells.
| M.Wt | 409.2313 | |
| Formula | C17H17BrN2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-.alpha.-cyano-3-(ethoxycarbonyl)-, ethyl ester, (.alpha.R,4R)-rel- |
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1. Wang JL, et al. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7124-9.
2. Milella M, et al. Blood. 2002 May 1;99(9):3461-4.
3. Chen J, et al. Mol Cancer Ther. 2002 Oct;1(12):961-7.
4. Lickliter JD, et al. Leukemia. 2003 Nov;17(11):2074-80.
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