Chemical Structure : HA14-1
CAS No.:
65673-63-4
HA14-1
(HA-14-1, HA 14-1)
Catalog No. : PC-42826Not For Human Use, Lab Use Only.
HA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM, induces apoptosis of tumor cells.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4282601
Biological Activity
HA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM, induces apoptosis of tumor cells.
Physicochemical Properties
M.Wt
409.2313
Formula
C17H17BrN2O5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-.alpha.-cyano-3-(ethoxycarbonyl)-, ethyl ester, (.alpha.R,4R)-rel-
References
1. Wang JL, et al. Proc Natl Acad Sci U S A.
2. Milella M, et al. Blood.
3. Chen J, et al. Mol Cancer Ther.
4. Lickliter JD, et al. Leukemia.
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