Chemical Structure : HBF-0259
CAS No.: 957011-15-3
Catalog No.: PC-24766Not For Human Use, Lab Use Only.
HBF-0259 is a specific and novel inhibitor of hepatitis B virus surface antigen (HBsAg) secretion with EC50 of 1.5 uM in HepDE19 cell line.
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HBF-0259 is a specific and novel inhibitor of hepatitis B virus surface antigen (HBsAg) secretion with EC50 of 1.5 uM in HepDE19 cell line.
HBF-0259 reduces HBV particle secretion without affecting viral replication.
HBF-0259 inhibits secretion of transiently expressed HBV envelope proteins.
HBF-0259 shows no effect on HSV-1 and BVDV, indicating it's selectivity.
M.Wt | 364.21 | |
Formula | C16H12Cl2FN5 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
7-(2 chloro-6-fluoro-phenyl)-5-(4-chorophenyl)-4,5,6,7-tetrahydro-tetrazolo[1,5-a]pyrimidine |
1. Dougherty AM, et al. Antimicrob Agents Chemother. 2007 Dec;51(12):4427-37.
2. Yu W, et al. J Med Chem. 2011 Aug 25;54(16):5660-70.
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