Chemical Structure : HBV RNaseH inhibitor 1466
CAS No.:
HBV RNaseH inhibitor 1466
(CAM-I 1466)
Catalog No.: PC-23940Not For Human Use, Lab Use Only.
HBV RNaseH inhibitor 1466 is a small molecule inhibitor of HBV RNaseH, inhibits HBV replication with EC50 of 0.25 uM, decreases capsid and core protein accumulation in HepDES19 and HepG2.2.15 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HBV RNaseH inhibitor 1466 is a small molecule inhibitor of HBV RNaseH, inhibits HBV replication with EC50 of 0.25 uM, decreases capsid and core protein accumulation in HepDES19 and HepG2.2.15 cells.
1466 does not affect pregenomic RNA encapsidation, demonstrating a specific effect on empty capsids.
1466 also decreased capsid and core protein accumulation in cells transfected with a core protein expression plasmid, indicating that other HBV products are unneeded.
HBV RNaseH inhibitor 1466 is a new class of capsid assembly modulators (CAM) that inhibits capsid assembly, targeting the RNaseH and capsid assembly.
Physicochemical Properties
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M.Wt
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322.75
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Formula
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C15H15ClN2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-5-(1-(((4-chlorobenzyl)oxy)imino)ethyl)-1,6-dihydroxy-4-methylpyridin-2(1H)-one
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References
1. Bradley DP, et al. PLoS Pathog. 2025 Feb 10;21(2):e1012920.
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