Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : HDAC1/2-IN-2
Catalog No.: PC-61915Not For Human Use, Lab Use Only.
HDAC1/2-IN-2 is a potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
HDAC1/2-IN-2 is a potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively.
HDAC1/2-IN-2 displays highly selectivity over HDAC3 (IC50=7.0 μM), HDAC8 and 11 (IC50=20-25 uM) and no activity on HDACs 4-7.
HDAC1/2-IN-2 increases lysine 5 of histone H2B (H2BK5) in HCT116 colon carcinoma cells with IC50 of 400 nM, inhibited the cell growth with GI50 of 97 nM.
HDAC1/2-IN-2 exhibits tumor growth inhibition in HCT116 xenograft mice.
| M.Wt | 449.529 | |
| Formula | C23H23N5O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Hamblett CL, et al. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5300-9.
2. Methot JL, et al. ACS Med Chem Lett. 2014 Jan 2;5(4):340-5.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
