HDAC6 PROTAC 17c

Chemical Structure : HDAC6 PROTAC 17c

Catalog No.: PC-24265Not For Human Use, Lab Use Only.

HDAC6 PROTAC 17c is a potent, selective CRBN- and VHL-recruiting PROTAC degrader of HDAC6 with DC50 of 14 nM in MM.1S cells, Dmax of 91%, high selective over other HDACs.

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Biological Activity

HDAC6 PROTAC 17c is a potent, selective CRBN- and VHL-recruiting PROTAC degrader of HDAC6 with DC50 of 14 nM in MM.1S cells, Dmax of 91%, high selective over other HDACs.

Physicochemical Properties

M.Wt	767.82
Formula	C39H42FN9O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-{[1-(6-{[2-(2,6-Dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl]amino}hexyl)-1H-1,2,3-triazol-4-yl]methoxy}-N-[4-(2-ethylhydrazine-1-carbonyl)benzyl]benzamide

References

1. Stopper D,et al. ACS Med Chem Lett. 2025 Feb 19;16(3):487-495.

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HDAC6 PROTAC 17c

Biological Activity

Physicochemical Properties

References

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