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Chemical Structure : HDAC6 degrader 9c
Catalog No.: PC-35282Not For Human Use, Lab Use Only.
HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand.
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HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand.
HDAC6 degrader 9c causes degradation of HDAC6 in a dose dependent manner (DC50=34 nM), upregulate the level of acetylated α-tubulin at 1.1 uM.
HDAC6 degrader 9c shows the maximal effect of HDAC6 degradation at 80 nM in the MM.1S cell line.
| M.Wt | 775.82 | |
| Formula | C37H45N9O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tan S, et al. Bioorg Med Chem. 2017 Aug 1;25(15):4123-4132.
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