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Chemical Structure : HDAC8-IN-22d
CAS No.: 1417997-93-3
Catalog No.: PC-63481Not For Human Use, Lab Use Only.
HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM, exhibits no activity against other HDACs and limited activity against HDAC1 and 3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM, exhibits no activity against other HDACs and limited activity against HDAC1 and 3.
HDAC8-IN-22d shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5).
HDAC8-IN-22d exhibits cytotoxicity against human lung CL1-5 cells (IC50=7.0 uM) similar to that of SAHA yet without significant cytotoxicity for normal IMR-90 cells.
| M.Wt | 345.398 | |
| Formula | C22H19NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide |
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1. Huang WJ, et al. ChemMedChem. 2012 Oct;7(10):1815-24.
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