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HEAL-116

Chemical Structure : HEAL-116

CAS No.: 3059767-85-7

HEAL-116 (HEAL116)

Catalog No.: PC-24810Not For Human Use, Lab Use Only.

HEAL-116 is a potent, selective 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) inhibitor, shows binding specificity to the substrate-binding pocket of 3βHSD1 and effectively neutralizes the local charge environment.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HEAL-116 is a potent, selective 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) inhibitor, shows binding specificity to the substrate-binding pocket of 3βHSD1 and effectively neutralizes the local charge environment.
HEAL-116 robustly inhibits 3βHSD1 activity and exerts pronounced antitumor effect in biochemical, cellular, and mouse models.

Physicochemical Properties

M.Wt 371.82
Formula C20H18ClNO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(4-Chloro-3-(morpholinomethyl) phenyl)-7-hydroxy-4H-chromen-4-one

References

1. He D, et al. Proc Natl Acad Sci U S A. 2025 Jul;122(26):e2422267122.

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