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HEC72702

Chemical Structure : HEC72702

CAS No.: 1793063-59-8

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HEC72702 (HEC-72702;HEC 72702)

Catalog No.: PC-63328Not For Human Use, Lab Use Only.

HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM.
    HEC72702 displays no induction of the CYP1A2, CYP3A4, or CYP2B6 enzyme at 10 uM.
    HEC72702 demonstrates a good systemic exposure and high oral bioavailability and achieves a viral-load reduction greater than 2 log in a hydrodynamic-injected (HDI) HBV mouse model.

    Physicochemical Properties

    M.Wt 581.457
    Formula C24H26BrFN4O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((R)-4-(((R)-6-(2-Bromo-4- fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)- 3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic acid

    References

    1. Ren Q, et al. J Med Chem. 2018 Feb 8;61(3):1355-1374.

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