HER2-IN-2 |CAS:2011708-43-1 Probechem Biochemicals

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Chemical Structure : HER2-IN-2

HER2-IN-2

Catalog No.: PC-62303Not For Human Use, Lab Use Only.

HER2-IN-2 is a potent, selective HER2 inhibitor, only shows potent inhibition for EGFR and Abl in a panel of kinases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HER2-IN-2 is a potent, selective HER2 inhibitor, only shows potent inhibition for EGFR and Abl in a panel of kinases.
HER2-IN-2 is equipotent to lapatinib against HER2 in vitro, also able to inhibit the small amount of HER3 auto-phosphorylation.
HER2-IN-2 inhibits 2YF/3TM gatekeeper mutant Ba/F3 cells lines with IC50 of 18.63 nM.

Physicochemical Properties

M.Wt	373.372
Formula	C20H15N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(furan-2-yl)-N-(5-(furan-2-yl)-2-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

References

1. Novotny CJ, et al. Nat Chem Biol. 2016 Nov;12(11):923-930.

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HER2-IN-2

Biological Activity

Physicochemical Properties

References

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