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HER2-IN-3

Chemical Structure : HER2-IN-3

CAS No.: 2011708-45-3

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HER2-IN-3

Catalog No.: PC-62304Not For Human Use, Lab Use Only.

HER2-IN-3 is a type I HER2 inhibitor that has a similar profile to HER2-IN-2, inhibits the active HER2/HER3 heterodimer in multiple oncogenic settings.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HER2-IN-3 is a type I HER2 inhibitor that has a similar profile to HER2-IN-2, inhibits the active HER2/HER3 heterodimer in multiple oncogenic settings.
    HER2-IN-3 shows superior activity to lapatinib in the 2YF/3wt + NRG cells and specificity for this cell line.
    HER2-IN-3 remains sensitivity to HER2 mutations L755S (2YF-L755S/3wt), Y772_A775 dup (2YF-YVMA/3wt), and G776del_insVC (2YF-VC/3wt) cells.

    Physicochemical Properties

    M.Wt 372.388
    Formula C20H16N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-(furan-3-yl)-2-methoxyphenyl)-5-(1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

    References

    1. Novotny CJ, et al. Nat Chem Biol. 2016 Nov;12(11):923-930.

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