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HFI-419

Chemical Structure : HFI-419

CAS No.: 1110650-72-0

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HFI-419 (HFI 419)

Catalog No.: PC-21697Not For Human Use, Lab Use Only.

HFI-419 is a specifc inhibits of insulin-regulated aminopeptidase (IRAP) with Ki of 0.48 uM, potent inhibits the hydrolysis of the dipeptidic substrate L-Leucine-7-amido-4-methylcoumarin with IC50 of 0.4 uM, >1000-fold lower or no affinity for related and unrelated enzymes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HFI-419 is a specifc inhibits of insulin-regulated aminopeptidase (IRAP) with Ki of 0.48 uM, potent inhibits the hydrolysis of the dipeptidic substrate L-Leucine-7-amido-4-methylcoumarin with IC50 of 0.4 uM, >1000-fold lower or no affinity for related and unrelated enzymes.

    Physicochemical Properties

    M.Wt 354.36
    Formula C19H18N2O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl 2-acetamido-7-hydroxy-4-(pyridin-3-yl)-4H-chromene-3-carboxylate

    References

    1. Anthony L Albiston, et al. FASEB J. 2008 Dec;22(12):4209-17.

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