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HG-12-6

Chemical Structure : HG-12-6

CAS No.: 2222354-57-4

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HG-12-6 (IRAK4 inhibitor)

Catalog No.: PC-36036Not For Human Use, Lab Use Only.

HG-12-6 is a small-molecule inhibitor that bind preferentially to unphosphorylated IRAK4 with IC50 of 165.1 nM, displays 15-fold selectivity over phosphorylated IRAK4 (IC50=2876 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HG-12-6 is a small-molecule inhibitor that bind preferentially to unphosphorylated IRAK4 with IC50 of 165.1 nM, displays 15-fold selectivity over phosphorylated IRAK4 (IC50=2876 nM).
    HG-12-6 binds as type II inhibitor with IRAK4 in a “DFG-out” conformation.

    Physicochemical Properties

    M.Wt 580.63
    Formula C29H27F3N6O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-5-yl)-N-(4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl)benzamide

    References

    1. Wang L, et al. J Biol Chem. 2019 Jan 24. pii: jbc.RA118.005428. doi: 10.1074/jbc.RA118.005428.

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