HIFN

Chemical Structure : HIFN

Catalog No.: PC-24269Not For Human Use, Lab Use Only.

HIFN is a novel and more potent TrkB activator than HIOC, exhibits heightened TrkB activity in NIH-3T3-TrkB cells at 10 nM.

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Biological Activity

HIFN is a novel and more potent TrkB activator than HIOC, exhibits heightened TrkB activity in NIH-3T3-TrkB cells at 10 nM.
HIFN reduces retinal and visual function deficits following ocular trauma.
HIFN demonstrated neuroprotection in an animal model of overpressure ocular blast injury, ameliorating blast-related visual functional decline. HIFN exhibited better protective effects than HIOC.

Physicochemical Properties

M.Wt	299.31
Formula	C16H14FN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-fluoro-N-(2-(5-hydroxy-1H-indol-3-yl) ethyl) nicotinamide

References

1. Modgil S, et al. bioRxiv [Preprint]. 2025 Feb 23:2025.02.18.638863.

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HIFN

Biological Activity

Physicochemical Properties

References

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