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HIV-1 inhibitor 18A

Chemical Structure : HIV-1 inhibitor 18A

CAS No.: 331261-50-8

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HIV-1 inhibitor 18A (Compound 18A)

Catalog No.: PC-62258Not For Human Use, Lab Use Only.

HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM; inhibits the CD4-induced disruption of quaternary structures at the trimer apex and the exposure of the gp41 HR1 coiled coil, does not interfere with CD4 or CCR5 binding.

Physicochemical Properties

M.Wt 313.33
Formula C14H11N5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-2,1,3-Benzothiadiazol-4-yl-2-[(4-hydroxyphenyl)methylene]-hydrazinecarboxamide

References

1. Herschhorn A, et al. Nat Chem Biol. 2014 Oct;10(10):845-52.

2. Berinyuy E, et al. J Recept Signal Transduct Res. 2016;36(2):119-29.

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