Chemical Structure : HIV-1 inhibitor 5b
CAS No.:
HIV-1 inhibitor 5b
Catalog No.: PC-36158Not For Human Use, Lab Use Only.
HIV-1 inhibitor 5b is a novel anti-HIV-1 compound that inhibits HIV-1 JR-CSF with EC50 of 1 nM without significant cytotoxicity (CC50>20 uM), also shows potency against NRTI- and NNRTI-resistant HIV-1 (EC50=1-3 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HIV-1 inhibitor 5b is a novel anti-HIV-1 compound that inhibits HIV-1 JR-CSF with EC50 of 1 nM without significant cytotoxicity (CC50>20 uM), also shows potency against NRTI- and NNRTI-resistant HIV-1 (EC50=1-3 nM); shows a chemical backbone similar to the clinically used integrase (IN) strand transfer inhibitor (INSTI) elvitegravir, but has no detectable INSTI activity; various drug-resistant HIV-1 strains did not display cross resistance to HIV-1 inhibitor 5b; remains its anti-HIV-1 activity even after the viral integration stage, significantly suppresses p24 antigen production in HIV-1 latently infected cells exposed with TNF-alpha; demonstrates favorable pharmacokinetic profiles in mice.
Physicochemical Properties
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M.Wt
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369.372
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Formula
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C20H17F2N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(5-amino-2,4-difluorophenyl)-7-(3,5-dimethyl-4,5-dihydroisoxazol-4-yl)quinolin-4(1H)-one
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References
1. Shiroishi-Wakatsuki T, et al. Antiviral Res. 2019 Feb;162:101-109.
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