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HIV InSTI-1

Chemical Structure : HIV InSTI-1

CAS No.: 1549802-58-5

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HIV InSTI-1 (HIV integrase strand transfer inhibitor 1)

Catalog No.: PC-60406Not For Human Use, Lab Use Only.

HIV InSTI-1 is a potent HIV integrase strand transfer inhibitor (InSTIs) with IC50 of 8 nM in HIV replication assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HIV InSTI-1 is a potent HIV integrase strand transfer inhibitor (InSTIs) with IC50 of 8 nM in HIV replication assay.
    HIV InSTI-1 shows Mutant Fold Shift 1/1/1/1/2/4 for E92Q/Y143R/Q148R/Q148K/N155H/G140S-Q148H compared with WT enzyme, respectively.
    HIV InSTI-1 demonstrates desired virological profile and preclinical pharmacokinetic profile.

    Physicochemical Properties

    M.Wt 501.939
    Formula C25H25ClFN3O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2R,5S)-8'-(3-chloro-4-fluorobenzyl)-6'-hydroxy-2'-((S)-2-hydroxypropyl)-9',10'-dihydro-2'H-spiro[bicyclo[3.1.0]hexane-2,3'-imidazo[5,1-a][2,6]naphthyridine]-1',5',7'(8'H)-trione

    References

    1. Schreier JD, et al. Bioorg Med Chem Lett. 2017 May 1;27(9):2038-2046.

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