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HIV capsid modulator 5-33d

Chemical Structure : HIV capsid modulator 5-33d

CAS No.:

HIV capsid modulator 5-33d

Catalog No.: PC-27767Not For Human Use, Lab Use Only.

HIV capsid modulator 5-33d is a potent HIV capsid modulator, exhibits potent antiviral activity with EC50 of 0.14 uM, exhibits potent binding affinities to the CA hexamer with KD of 59.0 nM, but not CA monomer.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HIV capsid modulator 5-33d is a potent HIV capsid modulator, exhibits potent antiviral activity with EC50 of 0.14 uM, exhibits potent binding affinities to the CA hexamer with KD of 59.0 nM, but not CA monomer.
5-33d exerts dual-stage inhibition by disrupting CA-host binding and modulating capsid assembly.

Physicochemical Properties

M.Wt 684.75
Formula C32H31F3N6O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-N-(1-(5-((2-(cyclopropanesulfonamido)ethyl)thio)-4-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)-2-(3,5-difluorophenyl)ethyl)-2-(5-fluoro-1H-indol-3-yl)acetamide

References

1. Jiang X, et al. J Med Chem. 2026 Aug 13;69(15):18783-18799.

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