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HJC0416

Chemical Structure : HJC0416

CAS No.: 1617518-22-5

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HJC0416 (HJC-0416, HJC 0416)

Catalog No.: PC-60500Not For Human Use, Lab Use Only.

HJC0416 is an orally bioavailable small-molecule STAT3 inhibitor, decreases the STAT3 promoter activity in MDA-MB-231 cells with IC50 of 5 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HJC0416 is an orally bioavailable small-molecule STAT3 inhibitor, decreases the STAT3 promoter activity in MDA-MB-231 cells with IC50 of 5 uM.
    HJC0416 inhibits the proliferation of both ER-positive, and ER-negative (triple negative) breast cancer cells with IC50 values of 1.76 uM and 1.97 uM, respectively.
    HJC0416 inhibits cell cycle progression and promotes apoptosis both in vitro and in vivo.

    Physicochemical Properties

    M.Wt 392.854
    Formula C18H17ClN2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(3-Aminopropoxy)-5-chloro-N-(1,1-dioxo-1H-1λ6-benzo[b]thiophen-6-yl)benzamide

    References

    1. Chen H, et al. Eur J Med Chem. 2014 Jul 23;82:195-203.

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