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HL-43

Chemical Structure : HL-43

CAS No.: 2287258-85-7

HL-43 (EP4 antagonist HL-43)

Catalog No.: PC-38004Not For Human Use, Lab Use Only.

HL-43 (EP4 antagonist HL-43) is a selective prostaglandin E receptor 4 (EP4) antagonist, promotes chondrocyte differentiation/cartilage regeneration and anabolism with low toxicity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HL-43 (EP4 antagonist HL-43) is a selective prostaglandin E receptor 4 (EP4) antagonist, promotes chondrocyte differentiation/cartilage regeneration and anabolism with low toxicity.
    HL-43 exhibits the highest potency in inducing Col2a1 expression and reducing Mmp3 expression in presence of IL-1β.
    HL-43 downregulats Mmp3/13 expression in a dose-dependent manner. HL-43 induces anabolic factors (ACAN and SOX9), and suppresses catabolic factor (MMP13), and hypertrophic marker (COLX), inhibits the STAT3 catabolic pathway.
    HL-43 promotes chondrocyte differentiation and ECM generation, and inhibits matrix degradation in both human and mouse articular cartilage explants.
    HL-43 enhances cartilage repair and regeneration in different artilage defect (CD) animal models.

    Physicochemical Properties

    M.Wt 474.492
    Formula C26H23FN4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-4-(1-(1-(2-(4-fluorophenoxy)ethyl)-4-phenyl-1H-1,2,3-triazole-5-carboxamido)ethyl)benzoic acid

    References

    1. Yunyun Jin, et al. Cell Discov. 2022 Mar 8;8(1):24.

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