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HMCEF

Chemical Structure : HMCEF

CAS No.: 2002363-68-8

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HMCEF (P-selectin inhibitor)

Catalog No.: PC-60181Not For Human Use, Lab Use Only.

HMCEF is a small molecule P-selectin inhibitor that directly binds to P-selectin, intercalates into calf thymus DNA, cuts off DNA pBR22 and inhibits the proliferation of cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HMCEF is a small molecule P-selectin inhibitor that directly binds to P-selectin, intercalates into calf thymus DNA, cuts off DNA pBR22 and inhibits the proliferation of cancer cells.
    HMCEF dose dependently inhibits inflammatory response of mice and inhibits thrombosis and inflammation, decreases serum TNFα and IL-8.

    Physicochemical Properties

    M.Wt 389.455
    Formula C23H23N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2-(3-(hydroxymethyl)-9H-pyrido[3,4-b]indol-1-yl)ethyl)-L-phenylalanine

    References

    1. Wu J, et al. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4631-6.

    2. Wu J, et al. Drug Des Devel Ther. 2017 Jan 17;11:225-239.

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