HMN-214 |CAS:173529-46-9 Probechem Biochemicals

Chemical Structure : HMN-214

CAS No.: 173529-46-9

HMN-214 (IVX-214;HMN214;TV-7101;IVX 214;;IVX214)

Catalog No.: PC-42860Not For Human Use, Lab Use Only.

HMN-214 (IVX 214, TV-7101) is a prodrug of HMN-176 for oral administration, HMN-176 is a stilbene derivative that interferes with the subcellular spatial location of PLK1, does not inhibit PLK directly.

Packing	Price	Stock
10 mg	$98	In stock
25 mg	$148	In stock
50 mg	$238	In stock
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

HMN-214 (IVX 214, TV-7101) is a prodrug of HMN-176 for oral administration, HMN-176 is a stilbene derivative that interferes with the subcellular spatial location of PLK1, does not inhibit PLK directly.
HMN-214 suppresses the expression of MDR1 mRNA in mouse xenograft model implanted with KB-A.1, an Adriamycin-resistant cell line.
HMN-176 inhibits the Y-box-dependent promoter activity of the MDR1 gene in a dose-dependent manner.

Physicochemical Properties

M.Wt	424.4696
Formula	C22H20N2O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, N-[(4-methoxyphenyl)sulfonyl]-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-

References

1. Tanaka H, et al. Cancer Res. 2003 Oct 15;63(20):6942-7.

2. Takagi M, et al. Invest New Drugs. 2003 Nov;21(4):387-99.

3. Garland LL, et al. Clin Cancer Res. 2006 Sep 1;12(17):5182-9.

4. Christensen MD, et al. J Control Release. 2015 Apr 28;204:20-9.

HMN-214 (IVX-214;HMN214;TV-7101;IVX 214;;IVX214)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.