Pynegabine (HN37) | Kv7.2/7.3 activator

Chemical Structure : HN37

CAS No.: 1821222-10-9

HN37 (Pynegabine)

Catalog No.: PC-27788Not For Human Use, Lab Use Only.

Pynegabine (HN37) is a novel, next-generation positive allosteric modulator/activator of KCNQ2/3 (Kv7.2/7.3) potassium with EC50 of 37 nM ( KCNQ2), shows antiepileptic activity.

Packing	Price	Stock
5 mg	$198	In stock
10 mg	$328	In stock
25 mg	$528	In stock
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Biological Activity

Pynegabine (HN37) is a novel, next-generation positive allosteric modulator/activator of KCNQ2/3 (Kv7.2/7.3) potassium with EC50 of 37 nM ( KCNQ2), shows antiepileptic activity.

Physicochemical Properties

M.Wt	340.40
Formula	C20H21FN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl (4-((4-fluorobenzyl)(prop-2-yn-1-yl)amino)-2,6-dimethylphenyl)carbamate

References

1. Yang-Ming Zhang, et al. J Med Chem. 2021 May 13;64(9):5816-5837.

2. Ma D, et al. Nat Commun. 2023 Oct 19;14(1):6632.

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HN37 (Pynegabine)

Biological Activity

Physicochemical Properties

References

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