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HNPMI

Chemical Structure : HNPMI

CAS No.: 1980848-48-3

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HNPMI

Catalog No.: PC-20818Not For Human Use, Lab Use Only.

HNPMI is a small molecule inhibitor of epidermal growth factor receptor (EGFR) with the anticancer potential against various cancers.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HNPMI is a small molecule inhibitor of epidermal growth factor receptor (EGFR) with the anticancer potential against various cancers.
HNPMI significantly reduced the cell proliferation of MCF-7 and SkBr3 cells, without affecting non-cancerous cells, H9C2.
HNPMI induces G0/G1 phase arrest in CRC cells.
HNPMI altered several apoptotic-related proteins including Caspase 3, BCL-2, and p53.
HNPMI significantly downregulated the crucial proteins associated with oncogenesis in CRC cells.
HNPMI reduced tumor volume in xenograft mice.

Physicochemical Properties

M.Wt 360.41
Formula C22H20N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

CC1=CC=C(C(N2CCC3=C2C=CC=C3)C4=CC([N+]([O-])=O)=CC=C4O)C=C1

References

1. Kandhavelu J, et al. Br J Pharmacol. 2023 May 15. doi: 10.1111/bph.16141.

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