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Chemical Structure : HO-3867
CAS No.: 1172133-28-6
Catalog No.: PC-42160Not For Human Use, Lab Use Only.
HO-3867 is a synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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HO-3867 is a synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.
HO-3867 induces G2-M cell cycle arrest in A2780 cells by modulating cell cycle regulatory molecules p53, p21, p27, CDK 2, and cyclin, and promotes apoptosis.
HO-3867 inhibits pSTAT3 (Tyr705 and Ser727) and JAK1 and increases apoptotic markers cleaved caspase-3 and PARP in xenograft tumor tissues.
| M.Wt | 464.5468 | |
| Formula | C28H30F2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
4-Piperidinone, 1-[(2,5-dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-, (3E,5E)- |
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1. Rath KS, et al. Cancer Res. 2014 Apr 15;74(8):2316-27.
2. Selvendiran K, et al. Mol Cancer Ther. 2010 May;9(5):1169-79.
3. Selvendiran K, et al. Cancer Biol Ther. 2011 Nov 1;12(9):837-45.
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