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Chemical Structure : HP590
CAS No.:
Catalog No.: PC-20357Not For Human Use, Lab Use Only.
HP590 is a highly potent, and orally bioavailable STAT3 inhibitor with IC50 of 27.8 nM, inibits IL-6 induced of the p-STAT3 Tyr705 and p-Ser727 activation in GC cells with lower nanomolar inhibitory activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $548 | In stock | |
| 25 mg | $898 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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HP590 (HP 590) is a highly potent, and orally bioavailable STAT3 inhibitor with IC50 of 27.8 nM, inibits IL-6 induced of the p-STAT3 Tyr705 and p-Ser727 activation in GC cells with lower nanomolar inhibitory activity.
HP590 selectively targets STAT3 to remarkably inhibit its canonical and noncanonical activation and corresponding biological functions, thereby resulting in the growth inhibition of gastric cancer in vitro and in vivo.
| M.Wt | 590.53 | |
| Formula | C29H24F6N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(4-(4-(2,2,2-trifluoroethoxy)benzyl)piperazin-1-yl)(4-(3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanone |
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1. Peng He, et al. J Med Chem. 2022 Oct 13;65(19):12650-12674.
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