HPK1-IN-3 | HPK1 inhibitor | Probechem Biochemicals

Chemical Structure : HPK1-IN-3

HPK1-IN-3 (HPK1 inhibitor 27)

Catalog No.: PC-22569Not For Human Use, Lab Use Only.

HPK1-IN-3 is a potent, selective, ATP-competitive hematopoietic progenitor kinase 1 (HPK1, MAP4K1) inhibitor with IC50 of 0.25 nM in TR-FRET assays.

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Biological Activity

HPK1-IN-3 is a potent, selective, ATP-competitive hematopoietic progenitor kinase 1 (HPK1, MAP4K1) inhibitor with IC50 of 0.25 nM in TR-FRET assays.
HPK1-IN-3 exhibits HPK1 target engagement with EC50 of 453 nM in PBMCs.
HPK1-IN-3 displays >100x selectivity in 252/265 kinases examined.

Physicochemical Properties

M.Wt	490.46
Formula	C23H22F4N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[[2-Fluoro-6-(trifluoromethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-5-pyrimidinecarboxamide

References

1. Brandon A Vara, et al. ACS Med Chem Lett. 2021 Mar 19;12(4):653-661.

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HPK1-IN-3 (HPK1 inhibitor 27)

Biological Activity

Physicochemical Properties

References

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