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Chemical Structure : HPK1 inhibitor 1
Catalog No.: PC-72013Not For Human Use, Lab Use Only.
HPK1 inhibitor 1 is a highly potent, selective inhibitor of HPK1/MAP4K1 with biochemical IC50 of 0.0465 nM.
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HPK1 inhibitor 1 is a highly potent, selective inhibitor of HPK1/MAP4K1 with biochemical IC50 of 0.0465 nM.
HPK1 inhibitor 1 displays >100-fold selectivity against 260 kinases in a panel of 265 kinases.
HPK1 inhibitor 1 decreased SLP-76 phosphorylation in a human pSLP-76 ELISA at an IC50 lower than 0.02 uM.
HPK1 inhibitor 1 enhanced Th1 cytokine production in T cells and fully reverted immune suppression imposed by the prostaglandin E2 (PGE2) and adenosine pathways in human T cells.
HPK1 inhibitor 1 demonstrated a synergistic effect, resulting in enhanced interferon (IFN)-γ production when combination with pembrolizumab in human PBMCs
| M.Wt | 474.544 | |
| Formula | C25H27FN8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Brian M Lacey, et al. SLAS Discov. 2021 Jan;26(1):88-99.
2. Yun Wang, et al. PLoS One. 2020 Dec 3;15(12):e0243145.
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